1995-03-01

The frequency of the epsilon 4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer's disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown. We found that the frequency of the apoE epsilon 4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the

2013. Stiftelsens intäkter. 123 085 116 587 111 245 Upplösning av Alzheimers sjukdom genom mikroglia-manipulation Den algebraiska strukturen hos epsilon-starkt graderade ringar. 200. Apolipoprotein E, type epsilon 4 allele (APOE epsilon 4), is associated with late-onset familial Alzheimer's disease (AD).

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1998; Ashford, 2004). The apolipoprotein E type 4 allele (APOE-[epsilon]4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-[epsilon]4 alleles in 42 families with late onset AD. 2017-01-01 · APOE [epsilon]4 allele frequencies were greater for patients with LOAD (33.9%) than for control subjects (6.0%). Furthermore, the statistical analysis showed that being a carrier of at least one APOE [epsilon]4 allele seems to be a significant risk factor for LOAD (OR = 7.286; 95% CI = 2.824-18.799; p < 0.001) (Table 3). 4.

[2] report that no association of the apoE epsilon 4 allele with cognitive decline was found in AD subjects.

Fingerprint Dive into the research topics of 'Infection and Alzheimer's disease: The APOE epsilon 4 connection and lipid metabolism'. Together they form a unique …

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This study confirms in a population sample that the epsilon 4 allele is a risk factor for dementia, but refutes the suggestion that homozygosity for the epsilon 4 allele is sufficient for the development of Alzheimer's disease: persons with either one or two epsilon 4 alleles may reach late old age without cognitive impairment.

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1996-03-21 The association of apoE epsilon 4 allele is not unique to Alzheimer's disease, and its importance as a risk factor for the disease should be reconsidered.
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2016; 12 (11): 1159–1166. Apr 12, 2019 Buckley RF, et al. (2018) Sex, amyloid, and APOE epsilon4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three  Sep 17, 2019 However, the relationship between APOE ɛ 4 gene dose, sex, and AD Alzheimer's Disease NeuroImaging Initiative (2014) APOE epsilon4 is  Sep 15, 2000 To date, only dominant genes have been linked with Alzheimer's disease. The epsilon 4 allele of the apolipoprotein E gene, or APOE-4,  May 30, 2019 may be important in the pathogenesis of early-onset Alzheimer's. the frequency of variants in apolipoprotein E epsilon 4 (APOE e4), APP,  Jun 18, 2008 “While having the APOE epsilon 4 allele increases the risk of developing Alzheimer's disease, APOE genotype alone is not enough to predict the  Apr 14, 2020 People with a gene variant that puts them at high risk for Alzheimer's disease are protected from its debilitating effects if they also carry a variant  Aug 2, 2018 Thanks to advances in genetic testing, there is now a way for consumers to test for the greatest genetic risk factor for late-onset Alzheimer's  Jun 27, 2018 0:00 / 4:31.

Aug 1, 1994 Apolipoprotein E epsilon 4 allele frequency in vascular dementia and Alzheimer's disease. · G B Frisoni · C Geroldi · A Bianchetti · M Trabucchi · S  Aug 20, 2020 APOE epsilon4 carriers may undergo synaptic damage conferring risk of Alzheimer's disease. Alzheimers Dement.
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2021-03-19 · OBJECTIVE: To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD). METHODS: Individuals were recruited from two longitudinal cohort studies-the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predictors Study (clinic-based)--and were followed for an average of 4 years.

Den visar sig ofta först i form av dåligt minne. Läs här om de tre stadierna av demenssjukdomen Alzheimer och hur symtomen kan lindras. Inheritance of the apolipoprotein E (apoE) epsilon 4 allele is associated with a high likelihood of developing Alzheimer's disease (AD). The pathophysiologic basis of this genetic influence is unknown. Apolipoprotein E ε-4 as a genetic determinant of Alzheimer’s disease heterogeneity The frequency of the epsilon 4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer's disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown.

Inheritance of the apolipoprotein E (apoE) epsilon 4 allele is associated with a high likelihood of developing Alzheimer's disease (AD). The pathophysiologic basis of this genetic influence is unknown.

(2008) APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology 70:  Genen APOE (epsilon)4 (apolipoprotein E e4) har kopplats till ökad risk för Alzheimers sjukdom.

Gov't; MeSH terms.